They proposed two main pathways of transmission that could originate from residues interacting either with adenine or with the -phosphate of ATP. The intracellularly caught misprocessed protein associates more with chaperone Hsp70, and the treatment with cyclosporine A reduces the association of mutant P-gp, therefore allowing it to become trafficked to the cell surface. The … Continue reading They proposed two main pathways of transmission that could originate from residues interacting either with adenine or with the -phosphate of ATP